RT Noah Smith 🐇🇺🇸🇺🇦🇹🇼: 那些家伙对mRNA的看法是错的。这是魔法。
Avi Roy指出，胰腺癌、胶质母细胞瘤、三阴性乳腺癌、肾癌和黑色素瘤这五种过去被视为死刑判决的癌症，如今通过个性化mRNA疫苗已实现完全缓解。转移性胰腺癌的中位生存期仍仅为6个月，胶质母细胞瘤为15个月，但mRNA技术正带来革命性突破。
相关报道
The Chan Zuckerberg Biohub Network has released a large-scale AI model called "World Model of Protein Biology" that can predict protein structures, interactions, and functions across diverse organisms. The model aims to accelerate biological discovery by providing a unified framework for understanding protein dynamics in their cellular context.
A phase 1b clinical trial tested Verve-102, a base-editing therapy targeting PCSK9, in patients with hypercholesterolemia. The treatment reduced LDL cholesterol levels, though some patients experienced infusion reactions. The study provides early evidence for in vivo base editing as a potential one-time treatment for high cholesterol.
Researchers have compressed the entirety of human cooking knowledge into a 2-megabyte dataset, aiming to advance AI understanding of cooking techniques and recipes. The project digitizes and condenses vast culinary information from diverse sources into a compact, accessible format for machine learning applications.
The article reviews biomarkers that change significantly with age, including grip strength, gait speed, telomere length, DNA methylation (epigenetic clocks), and levels of inflammatory markers like IL-6. It highlights which objective metrics show the most consistent and dramatic shifts as people grow older, and discusses how these measures can indicate biological age beyond chronological age.
FlavorDB is a database of flavor molecules, compounds responsible for taste and smell. It catalogues over 25,000 flavor compounds from various sources and maps their relationships in a network, linking molecules to foods and sensory descriptors. The resource is designed for researchers studying flavor chemistry, food science, and nutrition.